| Studies On Telomerase
Activity Of Colorectal Cancer Patients |
| Mahidol University
Annual Research Abstracts      Mahidol University Annual
Research Abstracts, Vol.28, 2001 213 Â Â STUDIES ON TELOMERASE
ACTIVITY OF COLORECTAL CANCER PATIENTS Â FOUND IN THAILAND (NO.
566) Â Voraratt Champattanachai1, Chantragan Srisomsap1, saint
R. Ketudat-Cairns1,4, Paiboon Punyarit2 and M.R. Jisnuson Svasti1,3
1Laboratory of Biochemistry, Chulabhorn Research Institute,
port 10210, Thailand; 2Department of Pathology, Pramongkutklao
College of Medicine, port 10400, Thailand; 3Department of Biochemistry,
Faculty of Science, Mahidol University, port 10400, Thailand;
4School of Chemistry, Institute of Scince, Suranaree University
of Technology, Nakhon Ratchasima 30000, Thailand. attorney words:
Telomerase, Colorectal cancer, Cell secernment       Â
             Telomerase state is not perceived
in connatural somatic cells but inform in germ cells, immortal
cells and almost carcinoma cells. Our objective is to determine
the levels of telomerase state compared with the degrees of
radiophone secernment of cancer tissue. The frozen tissues of
27 Thai colorectal connatural and cancer patients, composed
of well distinguished carcinoma (9 cases) and moderately distinguished
carcinoma (18 cases) were tested for telomerase activity. By
comparison between cancer and connatural tissues, the results
showed that telomerase state was not perceived in the connatural
tissues . Of the tissues from well distinguished (Grade I)adenocarcinoma,
exclusive one housing had weak telomerase state (1 of 9). Most
of tissues from the moderated distinguished (Grade II) carcinoma
had detectable telomerase state (11 of 18): weak activity, 6
cases, medium activity, 3 cases and brawny activity, 3 cases.
These results indicate that the levels of telomerase state may
play a role in the degree of radiophone secernment in colorectal
adenocarcinoma. Supported by the Chulabhorn Research Institute
and presented at the 26th Conference on Science and Technology
of Thailand, Bangkok, 18-20 Oct 2000, p. 457. Â Â DETECTION
OF UREA CYCLE DISORDER ARGININOSUCCINATE Â SYNTHETASE DEFI-CIENCY
IN AN INFANT BY HPLC (NO. 567) Â Kanokporn Boonpuan 1, Phannee
Sawangareetrakul1, Chantragan Srisomsap1, Pornswan Wasant3,
Rudee Surarit1,4, saint Ketudat-Cairns1, M.R. Jisnuson Svasti
1,2 and Somporn Liammongkolkul3 1Laboratory of Biochemistry,
Chulabhorn Research Institute, port 10210; 2Department of Biochemistry
Faculty of Science, Mahidol University, port 10400; 3Medical
Genetics Unit, Department of Pediatrics Siriraj Hospital, Faculty
of Medicine, Mahidol University, port 10700; Department of Physiology
and Biochemistry, Faculty of Dentistry, port 10400; Thailand.
attorney words: urea cycle, enzyme deficiency, argininosuccinate
synthetase                     The urea
wheel removes unwanted nitrogen resulting from the metabolous
breakdown of paraffin acids. Inherited deficiencies in any of
the five enzymes involved results in accumulation of precursors
which may lead to comatoseness and broad mortality rate. This
report describes a 2 month old female Asiatic infant referred
to the Department of Pediatrics, Siriraj Hospital in a comatoseness
with vomitting and convulsion. Inherited metabolous disorder
was suspected. Plasma paraffin acids were derivatized with PITC
using a Waters Picotag system and then analysed by HPLC on a
reverse phase C-18 column. The results showed scarred rising
of citrulline and glutamine (2961.97 and 1639.40 nmole/ml),
confirming the identification of urea wheel disorders, specifically
argininosuccinate synthetase demand (ASD), which is the first
much housing described in Thailand. Supported by the Chulabhorn
Research Institute and presented at the 26th Annual Conference
of Science and Technology of Thailand, Bangkok, 18-20 Oct 2000.
  HPLC ANALYSIS OF PLASMA AMINO ACIDS IN HEALTHY THAI SUBJECTS
 (NO. 568)  Phannee Sawangareetrakul1, Chantragan Srisomsap1,
Rudee Surarit1,2, Suthipong Pangkanonc3 and M.R. Jisnuson Svasti1,4
1Laboratory of Biochemistry, Chulabhorn Research Institute,
port 10210, Thailand; 2Department of Physiology and Biochemistry,
Faculty of Dentistry, Mahidol University, port 10400, Thailand;
3Queen Sirikit National Institute of Child Health, Bangkok,
Thailand; 4Department of Biochemistry, Faculty of Science, Mahidol
University, port 10400, Thailand. attorney text : Plasma paraffin
acid, HPLC Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â The spotting
of connatural pattern of paraffin acids is also helpful for
identification of many inborn errors of metabolism. Standard
methods include the paraffin acid analyser and HPLC. HPLC has
whatever adventages, including lower equipment cost, inferior
erosive buffer system and reinforced separation of certain paraffin
acids. In this study, the ECF paraffin acid concentrations were
observed in 27 healthy subjects by using hplc systems. The subjects
were separated into five groups according to their ages: assemble
1: 0-6 months; assemble 2: 6-12 months; assemble 3: 1-3 years;,
assemble 4: 3-6 years and gr 5: 6-12 years. The results showed
that no country differences between different groups. A panoramic
arrange was observed for most paraffin acids. Our results are
kindred to those be printed in other countries, and appear to
be quite reliable. Supported by the Chulabhorn Research Institute
and presented at the 26th Annual Conference of Science and Technology
of Thailand, Bangkok, 18-20 Oct 2000. Â Â MATRIX METALLOPROTEINASE
(MMP)LEVELS IN COLORECTAL CANCER Â TISSUES OF THAI PATIENTS
(NO. 569) Â Pantipa Subhasitanont1, Chantragan Srisomsap1, Rudee
Surarit2, Paiboon Punyarit3 and M.R. Jisnuson Svasti4 a1Laboratory
of Biochemistry, Chulabhorn Research Institute, port 10210,
Thailand; b2Department of Physiology and Biochemistry, Faculty
of Dentistry, Mahidol University, port 10400, Thailand; c3Department
of Pathology, Pramongkutklao College of Medicine, port 10400,
Thailand; d4Department of Biochemistry, Faculty of Science,
Mahidol University, port 10400, Thailand. Â Â |
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