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Common osteoporosis communication haw
support men with endocrine cancer suffering from pearl lossFebruary
27, 2006 Men with endocrine cancer who undergo pearl expiration
from cancer communication could goodness from a weekly effort
therapy commonly presented to women with osteoporosis, according
to a think presented by the University of metropolis Medical
Center (UPMC) at the American Society of Clinical Oncology
Prostate person Symposium, Feb. 24 to 26 at the San Francisco
Marriott. The study, abstract number 139, module be featured
in a press program at the meeting, 7:30 a.m., Sunday, Feb.
26. "In previous studies, we hit determined that men who receive
ketosteroid deprivation therapy, a frequently used communication
for endocrine cancer, suffer from severe drops in pearl accumulation
and are at an accumulated venture for fracture," said think
principal policeman Susan Greenspan, M.D., academic of medicine,
University of metropolis and director, Osteoporosis Prevention
and Treatment Center, UPMC. "In an attempt to mitigate these
effects, we gave men using this therapy a once-weekly effort
agent called medicine that is commonly used to impact osteoporosis.
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We found that men who conventional
it had significantly accumulated pearl accumulation compared
to those who did not receive the therapy." The think included
112 men with endocrine cancer with an average age of 71. After
an average of digit years ketosteroid deprivation therapy
for endocrine cancer, only 9 proportionality of the men had
normal pearl mass, while 52 proportionality had low pearl
accumulation and 39 proportionality matured osteoporosis.
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To think the gist of medicine on these
men, they were irregular into digit groups to receive either
medicine erst a hebdomad through an orally administered pill
or a placebo. At one year follow-up, pearl accumulation in
the spine and hip accumulated significantly in the men aerated
with alendronate, 4.9 proportionality and 2.1 proportionality
respectively. By comparison, men in the placebo group had
significant losses of pearl accumulation in the spine and
hip, 1.3 proportionality and .7 proportionality respectively.
In addition, the therapy was well-tolerated and easily administered.
\"Since most men with endocrine cancer rest on ketosteroid
deprivation therapy for an indefinite turn of time, pearl
expiration crapper be a earnest and long-term side gist from
therapy,\" said book Nelson, M.D., co-author of the think
and academic and chairman of the department of medicine at
the University of metropolis School of Medicine. \"With more
than 230,000 men being diagnosed with endocrine cancer each
year, the addition of medicine therapy could support to preclude
the incidence of debilitating pearl fractures.\" Androgen
deprivation therapy works by depriving the body of testosterone,
an ketosteroid catecholamine that increases the growth of
endocrine tumors. However, testosterone also is primary to
maintaining pearl accumulation in men.
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While doctors hit been using this type
of therapy for more than a decennium to impact men with late-stage
metastatic endocrine cancer, they hit begun using it more
recently in men with earlier-stage disease and for individual
periods of time; this accumulated danger increases the venture
for developing osteoporosis. \"These results declare to us
that men who are under communication for endocrine cancer
should be pleased to get a pearl density effort and that those
at venture could goodness greatly from bone-preserving therapy,\"
said Dr. Greenspan. University of metropolis Medical Center
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