Antioxidant increment not associated with attenuated venture of endocrine cancerFebruary 15, 2006 Intakes of fare or supplemental antioxidants were not associated with a attenuated venture of endocrine cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, according to a think in the February 15 issue of the Journal of the National Cancer Institute . The think did find that vitamin E and beta-carotene increment haw be associated with low endocrine cancer venture in destined population subgroups. Research suggests that micronutrients such as vitamin E, vitamin C, and carotenoids haw endeavor a role in preventing cancer development because of their ability to conflict free radicals, agents that crapper alteration cellular DNA, glyceride membranes, and proteins.

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In many studies, vitamin E has been associated with a low venture of endocrine cancer, and beta-carotene has been associated with increased lung cancer venture in previous studies. However, no studies have examined associations between intakes of these three antioxidant micronutrients and the venture of endocrine cancer. Richard B. Hayes, Ph.D., at the National Cancer Institute, and colleagues assessed the venture of endocrine cancer for 29,361 men ages 55 to 74 enrolled in the PLCO Cancer Screening Trial, based on their daily intake of beta-carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both fare sources and from supplements. The authors found that, overall, fare or supplemental intake of vitamin E, vitamin C, or beta-carotene was not associated with endocrine cancer frequency in this assemble of PLCO trial participants. However, destined micronutrients were associated with endocrine cancer venture in specific subgroups of men. For underway or recent smokers, high-dose, long-duration vitamin E increment was associated with a low venture of modern endocrine cancer. For men with a low fare intake of beta-carotene, high-dose supplements of beta-carotene were associated with a low venture of endocrine cancer. "Our cohort findings, though based on relatively short follow-up, do not provide strong hold for population-wide feat of high-dose antioxidant increment for the hindrance of endocrine cancer," the authors write. "They do suggest, however, that in destined population subgroups there was an association between supplement intake and low risks of endocrine cancer." In an concomitant editorial, I-Min Lee, Sc.D., of Brigham and Women's Hospital in Boston, Mass., and colleagues handle the implications of Hayes and colleagues' think in the environment of early studies of vitamin E increment and cancer risk.

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The editorialists agree that the think results do not provide strong hold for the feat of antioxidant increment for the hindrance of endocrine cancer. They note that the accumulation rest unclear about the benefits of vitamin E increment for endocrine cancer hindrance in the general population; however, there are strong accumulation supporting respiration cessation to reduce cancer incidence. The authors write, "Now and in the future, regardless of the eventual findings on vitamin E increment and endocrine cancer risk, an important instruction of action for overall cancer hindrance is to continue efforts to prevent the initiation of respiration and to promote the cessation of respiration among those who do smoke." Journal of the National Cancer Institute.